Abnormal liver-related biomarkers in COVID-19 patients and the role of prealbumin.
Identifieur interne : 000010 ( Main/Exploration ); précédent : 000009; suivant : 000011Abnormal liver-related biomarkers in COVID-19 patients and the role of prealbumin.
Auteurs : Tao Li [République populaire de Chine] ; Ying Guo [République populaire de Chine] ; Xianghua Zhuang [République populaire de Chine] ; Laigang Huang [République populaire de Chine] ; Xingqian Zhang [République populaire de Chine] ; Fengtao Wei [République populaire de Chine] ; Baohua Yang [République populaire de Chine]Source :
- Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association [ 1998-4049 ]
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Alanine transaminase (sang), Arabie saoudite (épidémiologie), Aspartate aminotransferases (sang), Betacoronavirus (MeSH), Bilirubine (sang), Comorbidité (MeSH), Femelle (MeSH), Humains (MeSH), Infections à coronavirus (sang), Infections à coronavirus (épidémiologie), Maladies du foie (sang), Maladies du foie (épidémiologie), Marqueurs biologiques (sang), Mâle (MeSH), Pandémies (MeSH), Pneumopathie virale (sang), Pneumopathie virale (épidémiologie), Pronostic (MeSH), Préalbumine (métabolisme), Sujet âgé (MeSH), Tests de la fonction hépatique (MeSH), Études de suivi (MeSH), Études rétrospectives (MeSH).
- MESH :
- métabolisme : Préalbumine.
- sang : Alanine transaminase, Aspartate aminotransferases, Bilirubine, Infections à coronavirus, Maladies du foie, Marqueurs biologiques, Pneumopathie virale.
- épidémiologie : Arabie saoudite, Infections à coronavirus, Maladies du foie, Pneumopathie virale.
- Adulte d'âge moyen, Betacoronavirus, Comorbidité, Femelle, Humains, Mâle, Pandémies, Pronostic, Sujet âgé, Tests de la fonction hépatique, Études de suivi, Études rétrospectives.
- Wicri :
- geographic : Arabie saoudite.
English descriptors
- KwdEn :
- Aged (MeSH), Alanine Transaminase (blood), Aspartate Aminotransferases (blood), Betacoronavirus (MeSH), Bilirubin (blood), Biomarkers (blood), Comorbidity (MeSH), Coronavirus Infections (blood), Coronavirus Infections (epidemiology), Female (MeSH), Follow-Up Studies (MeSH), Humans (MeSH), Liver Diseases (blood), Liver Diseases (epidemiology), Liver Function Tests (MeSH), Male (MeSH), Middle Aged (MeSH), Pandemics (MeSH), Pneumonia, Viral (blood), Pneumonia, Viral (epidemiology), Prealbumin (metabolism), Prognosis (MeSH), Retrospective Studies (MeSH), Saudi Arabia (epidemiology).
- MESH :
- chemical , blood : Alanine Transaminase, Aspartate Aminotransferases, Bilirubin, Biomarkers.
- geographic , epidemiology : Saudi Arabia.
- blood : Coronavirus Infections, Liver Diseases, Pneumonia, Viral.
- epidemiology : Coronavirus Infections, Liver Diseases, Pneumonia, Viral.
- chemical , metabolism : Prealbumin.
- Aged, Betacoronavirus, Comorbidity, Female, Follow-Up Studies, Humans, Liver Function Tests, Male, Middle Aged, Pandemics, Prognosis, Retrospective Studies.
Abstract
Background/Aims
We aimed to evaluate the distribution of abnormal liver-related biomarkers in patients with coronavirus disease (COVID-19) and explore the prognostic value of elevated liver enzymes and abnormal liver synthetic capacity with regards to patient mortality.
Patients and Methods
This retrospective observational study included 80 laboratory-confirmed COVID-19 cases. Data were collected from the electronic medical record system by a trained team of physicians. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TB), albumin, and prealbumin levels at admission and on day 7 after admission were collected. The primary outcome of the current study was patient mortality.
Results
Abnormal ALT, AST, TB, albumin, and prealbumin levels were observed in 11 (13.8%), 15 (18.8%), 5 (6.3%), 22 (27.5%), and 31 (38.8%) patients, respectively. Male gender correlated with elevated ALT and AST levels (p = 0.027 and 0.036, respectively). Higher levels of AST and lower levels of albumin and prealbumin were associated with patient mortality (p = 0.009, 0.002, and 0.003, respectively). Multivariate Cox regression analysis identified patient age (p = 0.013, HR 1.108) and prealbumin levels (p = 0.015, HR 0.986) as independent predictors for patient mortality. However, changes in liver-related biomarkers were not associated with poor outcome in multivariate analysis (p > 0.05).
Conclusions
Abnormalities in albumin and prealbumin levels are common among COVID-19 patients and hypoprealbuminemia independently predicts adverse outcome and should be carefully considered in clinical practice. Moreover, changes in liver-related biomarkers is not a salient feature of COVID-19.
DOI: 10.4103/sjg.SJG_239_20
PubMed: 32769260
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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wicri:level="1"><nlm:affiliation>Intensive Care Unit, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Intensive Care Unit, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan</wicri:regionArea><wicri:noRegion>Jinan</wicri:noRegion></affiliation></author><author><name sortKey="Zhuang, Xianghua" sort="Zhuang, Xianghua" uniqKey="Zhuang X" first="Xianghua" last="Zhuang">Xianghua Zhuang</name><affiliation wicri:level="1"><nlm:affiliation>Medical Team Backing Hubei Province; Endocrinology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Team Backing Hubei Province; Endocrinology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan</wicri:regionArea><wicri:noRegion>Jinan</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Laigang" sort="Huang, Laigang" uniqKey="Huang L" first="Laigang" last="Huang">Laigang Huang</name><affiliation wicri:level="1"><nlm:affiliation>Medical Team Backing Hubei Province; Rehabilitation Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Team Backing Hubei Province; Rehabilitation Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan</wicri:regionArea><wicri:noRegion>Jinan</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xingqian" sort="Zhang, Xingqian" uniqKey="Zhang X" first="Xingqian" last="Zhang">Xingqian Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Medical Team Backing Hubei Province; Cardiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Team Backing Hubei Province; Cardiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan</wicri:regionArea><wicri:noRegion>Jinan</wicri:noRegion></affiliation></author><author><name sortKey="Wei, Fengtao" sort="Wei, Fengtao" uniqKey="Wei F" first="Fengtao" last="Wei">Fengtao Wei</name><affiliation wicri:level="1"><nlm:affiliation>Medical Team Backing Hubei Province; Cardiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Medical Team Backing Hubei Province; Cardiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan</wicri:regionArea><wicri:noRegion>Jinan</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Baohua" sort="Yang, Baohua" uniqKey="Yang B" first="Baohua" last="Yang">Baohua Yang</name><affiliation wicri:level="1"><nlm:affiliation>Departments of Infectious Disease and Hepatolgy, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Departments of Infectious Disease and Hepatolgy, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan</wicri:regionArea><wicri:noRegion>Jinan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association</title><idno type="eISSN">1998-4049</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged (MeSH)</term><term>Alanine Transaminase (blood)</term><term>Aspartate Aminotransferases (blood)</term><term>Betacoronavirus (MeSH)</term><term>Bilirubin (blood)</term><term>Biomarkers (blood)</term><term>Comorbidity (MeSH)</term><term>Coronavirus Infections (blood)</term><term>Coronavirus Infections (epidemiology)</term><term>Female (MeSH)</term><term>Follow-Up Studies (MeSH)</term><term>Humans (MeSH)</term><term>Liver Diseases (blood)</term><term>Liver Diseases (epidemiology)</term><term>Liver Function Tests (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (blood)</term><term>Pneumonia, Viral (epidemiology)</term><term>Prealbumin (metabolism)</term><term>Prognosis (MeSH)</term><term>Retrospective Studies (MeSH)</term><term>Saudi Arabia (epidemiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Alanine transaminase (sang)</term><term>Arabie saoudite (épidémiologie)</term><term>Aspartate aminotransferases (sang)</term><term>Betacoronavirus (MeSH)</term><term>Bilirubine (sang)</term><term>Comorbidité (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (sang)</term><term>Infections à coronavirus (épidémiologie)</term><term>Maladies du foie (sang)</term><term>Maladies du foie (épidémiologie)</term><term>Marqueurs biologiques (sang)</term><term>Mâle (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (sang)</term><term>Pneumopathie virale (épidémiologie)</term><term>Pronostic (MeSH)</term><term>Préalbumine (métabolisme)</term><term>Sujet âgé (MeSH)</term><term>Tests de la fonction hépatique (MeSH)</term><term>Études de suivi (MeSH)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Alanine Transaminase</term><term>Aspartate Aminotransferases</term><term>Bilirubin</term><term>Biomarkers</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term><term>Liver Diseases</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Liver Diseases</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Prealbumin</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Préalbumine</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Alanine transaminase</term><term>Aspartate aminotransferases</term><term>Bilirubine</term><term>Infections à coronavirus</term><term>Maladies du foie</term><term>Marqueurs biologiques</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Arabie saoudite</term><term>Infections à coronavirus</term><term>Maladies du foie</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Betacoronavirus</term><term>Comorbidity</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Liver Function Tests</term><term>Male</term><term>Middle Aged</term><term>Pandemics</term><term>Prognosis</term><term>Retrospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Betacoronavirus</term><term>Comorbidité</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Pandémies</term><term>Pronostic</term><term>Sujet âgé</term><term>Tests de la fonction hépatique</term><term>Études de suivi</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Arabie saoudite</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Background/Aims</b></p><p>We aimed to evaluate the distribution of abnormal liver-related biomarkers in patients with coronavirus disease (COVID-19) and explore the prognostic value of elevated liver enzymes and abnormal liver synthetic capacity with regards to patient mortality.</p></div><div type="abstract" xml:lang="en"><p><b>Patients and Methods</b></p><p>This retrospective observational study included 80 laboratory-confirmed COVID-19 cases. Data were collected from the electronic medical record system by a trained team of physicians. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TB), albumin, and prealbumin levels at admission and on day 7 after admission were collected. The primary outcome of the current study was patient mortality.</p></div><div type="abstract" xml:lang="en"><p><b>Results</b></p><p>Abnormal ALT, AST, TB, albumin, and prealbumin levels were observed in 11 (13.8%), 15 (18.8%), 5 (6.3%), 22 (27.5%), and 31 (38.8%) patients, respectively. Male gender correlated with elevated ALT and AST levels (p = 0.027 and 0.036, respectively). Higher levels of AST and lower levels of albumin and prealbumin were associated with patient mortality (p = 0.009, 0.002, and 0.003, respectively). Multivariate Cox regression analysis identified patient age (p = 0.013, HR 1.108) and prealbumin levels (p = 0.015, HR 0.986) as independent predictors for patient mortality. However, changes in liver-related biomarkers were not associated with poor outcome in multivariate analysis (p > 0.05).</p></div><div type="abstract" xml:lang="en"><p><b>Conclusions</b></p><p>Abnormalities in albumin and prealbumin levels are common among COVID-19 patients and hypoprealbuminemia independently predicts adverse outcome and should be carefully considered in clinical practice. Moreover, changes in liver-related biomarkers is not a salient feature of COVID-19.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32769260</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>02</Day></DateCompleted><DateRevised><Year>2020</Year><Month>10</Month><Day>02</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1998-4049</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>5</Issue><PubDate><MedlineDate>2020 Sep-Oct</MedlineDate></PubDate></JournalIssue><Title>Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association</Title><ISOAbbreviation>Saudi J Gastroenterol</ISOAbbreviation></Journal><ArticleTitle>Abnormal liver-related biomarkers in COVID-19 patients and the role of prealbumin.</ArticleTitle><Pagination><MedlinePgn>272-278</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4103/sjg.SJG_239_20</ELocationID><Abstract><AbstractText Label="Background/Aims">We aimed to evaluate the distribution of abnormal liver-related biomarkers in patients with coronavirus disease (COVID-19) and explore the prognostic value of elevated liver enzymes and abnormal liver synthetic capacity with regards to patient mortality.</AbstractText><AbstractText Label="Patients and Methods">This retrospective observational study included 80 laboratory-confirmed COVID-19 cases. Data were collected from the electronic medical record system by a trained team of physicians. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TB), albumin, and prealbumin levels at admission and on day 7 after admission were collected. The primary outcome of the current study was patient mortality.</AbstractText><AbstractText Label="Results">Abnormal ALT, AST, TB, albumin, and prealbumin levels were observed in 11 (13.8%), 15 (18.8%), 5 (6.3%), 22 (27.5%), and 31 (38.8%) patients, respectively. Male gender correlated with elevated ALT and AST levels (p = 0.027 and 0.036, respectively). Higher levels of AST and lower levels of albumin and prealbumin were associated with patient mortality (p = 0.009, 0.002, and 0.003, respectively). Multivariate Cox regression analysis identified patient age (p = 0.013, HR 1.108) and prealbumin levels (p = 0.015, HR 0.986) as independent predictors for patient mortality. However, changes in liver-related biomarkers were not associated with poor outcome in multivariate analysis (p > 0.05).</AbstractText><AbstractText Label="Conclusions">Abnormalities in albumin and prealbumin levels are common among COVID-19 patients and hypoprealbuminemia independently predicts adverse outcome and should be carefully considered in clinical practice. Moreover, changes in liver-related biomarkers is not a salient feature of COVID-19.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Tao</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Medical Team Backing Hubei Province; Departments of Infectious Disease and Hepatolgy, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Ying</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Intensive Care Unit, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhuang</LastName><ForeName>Xianghua</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Medical Team Backing Hubei Province; Endocrinology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Laigang</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Medical Team Backing Hubei Province; Rehabilitation Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Xingqian</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Medical Team Backing Hubei Province; Cardiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Fengtao</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Medical Team Backing Hubei Province; Cardiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Baohua</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Departments of Infectious Disease and Hepatolgy, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>India</Country><MedlineTA>Saudi J Gastroenterol</MedlineTA><NlmUniqueID>9516979</NlmUniqueID><ISSNLinking>1319-3767</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011228">Prealbumin</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.6.1.1</RegistryNumber><NameOfSubstance UI="D001219">Aspartate Aminotransferases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.6.1.2</RegistryNumber><NameOfSubstance UI="D000410">Alanine Transaminase</NameOfSubstance></Chemical><Chemical><RegistryNumber>RFM9X3LJ49</RegistryNumber><NameOfSubstance UI="D001663">Bilirubin</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000410" MajorTopicYN="N">Alanine Transaminase</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001219" MajorTopicYN="N">Aspartate Aminotransferases</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001663" MajorTopicYN="N">Bilirubin</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008107" MajorTopicYN="N">Liver Diseases</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008111" MajorTopicYN="N">Liver Function Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011228" MajorTopicYN="N">Prealbumin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012529" MajorTopicYN="N" Type="Geographic">Saudi Arabia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">hypoprealbuminemia</Keyword><Keyword MajorTopicYN="Y">liver impairment</Keyword><Keyword MajorTopicYN="Y">prognosis</Keyword></KeywordList><CoiStatement>None</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>10</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32769260</ArticleId><ArticleId IdType="pii">291474</ArticleId><ArticleId IdType="doi">10.4103/sjg.SJG_239_20</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Li, Tao" sort="Li, Tao" uniqKey="Li T" first="Tao" last="Li">Tao Li</name></noRegion><name sortKey="Guo, Ying" sort="Guo, Ying" uniqKey="Guo Y" first="Ying" last="Guo">Ying Guo</name><name sortKey="Huang, Laigang" sort="Huang, Laigang" uniqKey="Huang L" first="Laigang" last="Huang">Laigang Huang</name><name sortKey="Wei, Fengtao" sort="Wei, Fengtao" uniqKey="Wei F" first="Fengtao" last="Wei">Fengtao Wei</name><name sortKey="Yang, Baohua" sort="Yang, Baohua" uniqKey="Yang B" first="Baohua" last="Yang">Baohua Yang</name><name sortKey="Zhang, Xingqian" sort="Zhang, Xingqian" uniqKey="Zhang X" first="Xingqian" last="Zhang">Xingqian Zhang</name><name sortKey="Zhuang, Xianghua" sort="Zhuang, Xianghua" uniqKey="Zhuang X" first="Xianghua" last="Zhuang">Xianghua Zhuang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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